According to New York One News Network quoting a spokesperson for the former first lady said she died this morning in her Los Angles home.
The former first lady had been living in Bel-Air California and had been in failing health in recent years.
Regan was a former actress before meeting her husband President Ronald Reagan, the two wed in 1952.
She was harshly criticized by others as first lady, for her fancy taste and renovations to the White House.
Reagan went on to be known as an “unofficial protector” of her husband after an assassination attempt in 1981.
During her time as first lady she created the “Just Say No” campaign as a way to educate young people about the effects of drugs.
Earlier today, Senator Charles Schumer reflected on her legacy.
“Nancy Reagan was a very, very strong person, you didn’t have to agree with her to respect her dramatically, to respect how she was always working hard with her husband to bring about the changes she thought was right,” Schumer said.
Funeral plans have not been announced, but The Reagan Foundation says that she will be buried at the Ronald Reagan Presidential Library next to her husband.
Nancy Reagan was 94-years-old.